Objectivekleine levin syndrome is a rare disorder characterized by relapsingremitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality. It is characterized by recurring but reversible periods of excessive sleep up to 20 hours per day. The first episode started when she was 15 years old. Kleine levin syndrome kls is a rare and complex disorder characterized by recurring periods of excessive sleep, as well as altered cognition and behavior. The name kleinelevin syndrome kls was coined by critchley and hoffman in 1942. Apr 24, 2018 objective to retrospectively compare the benefits episode cessation and risks of iv methylprednisolone ivmp vs abstention during prolonged kleine levin syndrome kls episodes. In a kls cohort followed in a single center, patients regularly took lithium carbonate median dose 1,000 mgday.
These serious episodes alternate with periods without any symptoms. Classification of sleep disorders,3 a monosymptomatic form of the syndrome with recurrent hypersomnia appear ing without binge. Many patients also experience hyperphagia, hypersexuality and other symptoms. Kleine levin syndrome kls, also called recurrent hypersomnia, is a rare sleep disorder characterized by recurrent episodes of severe hypersomnia associated with cognitive and behavioral disturbances such as confusion, derealization, apathy, compulsive eating, and hypersexuality. In my 1993 publication abnormal fluctuations of acetylcholine and serotonin medical hypotheses vol. Methods a total of 26 patients with kls received 1 gd ivmp for 3 days during 1 to 6 episodes each totaling 43 ivmp sessions. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent. Patients with kls, which is also called sleeping beauty disease, may sleep for days, weeks, or months, waking only to eat andor use the bathroom. Kleine levin syndrome genetic and rare diseases information. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral. Kleine levin syndrome kls is a rare disorder characterized by periodic hypersomnia associated with behavioural disturbances such as binge eating hyperphagia, irritability, and increased sexual interest hyper sexuality. Kleinelevin syndrome nord national organization for rare.
Iv steroids during long episodes of kleinelevin syndrome. It is a disease predominantly of teenagers, and boys are four times more likely to be affected than girls. Diagnosing kls is admittedly a challenge but can be a relief for a family in search of answers. Kleine levin syndrome can last for eight to fourteen years of an afflicted persons life, dr. In addition to sleepiness, individuals also have compulsive overeating and hypersexuality in primary hypersomnia, the excessive sleepiness happens over a period of many months, or sometimes, even for many years. Kleine levin syndrome is rare, affecting an estimated 15 per million individuals. This term refers to conditions that cause excessive daytime sleepiness, meaning that patients have trouble staying awake during the day 1. It is characterised by recurrent episodes of hypersomnia, usually accompanied by hyperphagia, cognitive and mood disturbances, abnormal behaviour, such as hypersexuality, and signs of dysautonomia. In some cases, this means up to 20 hours a day are spent sleeping. Affected individuals may sleep for up to 20 hours per day during an episode. The full text of this article is available in pdf format. Diagnosis, disease course, and management of patients with kleinelevin syndrome isabelle arnulf, thomas j rico, emmanuel mignot kleinelevin syndrome is a rare sleep disorder that mainly a.
Kleinelevin syndrome was first described by kleine in 1925 and elaborated on by levin in 1936, but it was critchley and hoffman who further defined the syndrome in 1942 and gave it its eponym. Several clinical symptoms also suggest an underlying autoimmune process. Kleinelevin syndrome information page national institute. To systematically investigate patients with kls with reference to the available. Kleine levin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world.
Jan 20, 2014 kleine levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. Kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Primary hypersomnias kleine levin syndrome overview. Les patients qui en sont atteints peuvent dormir 20 heures.
Because its primary symptom, hypersomnia, is common to a number of disorders, the process by which we diagnose kls is one of exclusion ruling out other conditions that share symptoms. Kleine levin syndrome kls is a rare neurological disorder which affects roughly 2000 known sufferers worldwide. This site is like a library, you could find million book here by using search box in the. Kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Kleinelevin syndrome kls is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Kleinelevin syndrome kls is a rare and complex disorder characterized by recurring periods of excessive sleep, as well as altered cognition and behavior.
While experiencing symptoms, patients sleep most of. In 1925, kleine, published a case of recurrent episodes of somnolence and morbid hunger and levin, in 1936, described a syndrome characterized by recurring periods of somnolence and morbid hunger. Kleinelevin syndrome does not affect me or a close family member. Kleinelevin syndrome kls is a rare sleep disorder characterized by recurrent and unusually long episodes of hypersomnia, associated with behavioralcognitive disturbances, megaphagia and more rarely sexual disinhibition.
Kleinelevin syndrome diagnosis stanford health care. Kleine levin syndrome kls is a rare disorder that mainly affects adolescent men. Because its primary symptom, hypersomnia, is common to a number of disorders, the process by which we diagnose kls is one of exclusion ruling out other conditions that share. Concurrence of immune thrombocytopenic purpura and kleinelevin syndrome supports the role of autoimmunity as the proposed pathophysiological mechanism of kleinelevin syndrome. The kleinelevin syndrome is a differential diagnosis for patients with diurnal excessive sleepiness and a suspicion of narcolepsy. It is a lifealtering illness which is widely misunderstood and frequently misdiagnosed as a psychological illness. Kls support uk helping families affected by kleinelevin. Concurrence of immune thrombocytopenic purpura and kleine levin syndrome supports the role of autoimmunity as the proposed pathophysiological mechanism of kleine levin syndrome. We collected detailed clinical data and blood samples on 108 patients, 79 parent pairs, and 108 matched control subjects. Federation des pathologies du sommeil, hopital pitie. Symptoms occur as episodes, typically lasting a few days to a few weeks. Patients generally experience recurrent episodes of the condition for more than a decade and may return at a later age. Kleinelevin syndrome nord national organization for. Kleine levin syndrome is a rare disorder characterized by relapsingremitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality.
Kleine levin syndrome kls is a rare disorder of unknown etiology. Kleine levin syndrome kls is a chronic sleep disorder and is one of the central disorders of hypersomnolence cdhs. Shimizu abstract a case of kleinelevin syndrome, with chronic severe periodic hypersomnia is described in a 17yearold female. Forgotten diseases research foundation kleinelevin. These episodes usually last for a few days to a few weeks. Kleinelevin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioural and cognitive disturbances, hyperphagia and in some cases hypersexuality.
While experiencing symptoms, patients sleep most of the day and night. Kleinelevin syndrome definition of kleinelevin syndrome. Associated symptoms include an abnormally uninhibited sex drive, irritability, and disorientation. Diagnosis, disease course, and management of patients with. Symptoms occur in cycles that can last anywhere from a few days to several weeks. It is characterized by paroxysmal attacks of diurnal excessive sleepiness, associated with one or more symptoms of hyperphagia, hypersexuality, coprolalia and copropraxia. The change of episode duration with ivmp vs previous episode duration was. Kleine levin syndrome diagnosis diagnosing kleine levin syndrome. The relationship between the two syndromes, the praderwilli syndrome and the kleine syndrome, deserves further study.
All books are in clear copy here, and all files are secure so dont worry about it. Learn about kleine levin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. Primary hypersomnias kleinelevin syndrome overview. The disorder strikes adolescents primarily but can occur in younger children and adults. Pathophysiologic hypotheses include a hypothalamic dysfunction and abnormalities in the central serotonin and dopamine metabolism. Mar 27, 2019 kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Jul 10, 2017 kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Kleine levin syndrome is a rare disorder characterized by the need for excessive amounts of sleep hypersomnolence, i. Eau claire wisconsin sleep specialist doctors physician directory learn about kleine levin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. Nature and science of sleep dovepress kls foundation. Rancurello said, noting that nicole is reaching the mean length of symptoms right now. Pharmacological treatment for kleinelevin syndrome cochrane. The relationship between the two syndromes, the praderwilli syndrome and the kleinesyndrome, deserves further study. Les jeunes affectes presentent brutalement des episodes dhypersomnie avec fatigue intense durant quelques jours.
Nicole delien born november 6, 1995 is known for bringing awareness in the media to kleine levin syndrome, a rare sleeping disorder that affects about 1,000 people around the world delien, often referred to in the media as the real life sleeping beauty, is a united states pennsylvania resident that was diagnosed with kleine levin syndrome kls when she was sixandahalf years old. Kleine levin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. To compare the benefits and risks of lithium therapy vs abstentionother treatments in kleine levin syndrome kls. Kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. A 4 yearold boy presented with excessive sleepiness for 3 days with a history of having sustained a head injury a week ago. Learn about kleinelevin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. Kleinelevin syndrome clinical course, polysomnography and multiple sleep latency test case report rubens reim. Kleinelevin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. The authors present a casereport of a 22yearold man with kleine levin syndrome kls and consider the historical description of the syndrome, its symptoms, diagnostic criteria, its place in. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Kleinelevin syndrome is a rare disorder characterized by relapsingremitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality. Oct 23, 2018 kleinelevin syndrome kls is a very uncommon sleep disorder. Kleine levin syndrome definition, prolonged episodes of excessive sleepiness often accompanied by overeating, hallucinations, and electroencephalogram changes, usually. Kleinelevin syndrome is a rare disorder characterized by the need for excessive amounts of sleep hypersomnolence, i.
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